KMID : 0613820150250101081
|
|
Journal of Life Science 2015 Volume.25 No. 10 p.1081 ~ p.1090
|
|
Allium hookeri Extract Improves Type 2 Diabetes Mellitus in C57BL/KSJ Db/db Obese Mouse via Regulation of Hepatic Lipogenesis and Glucose Metabolism
|
|
Kim Ji-Soo
Heo Jin-Sun Choi Jong-Won Kim Kun-Do Sohn Gee-Ho
|
|
Abstract
|
|
|
Diabetes has been one of major health risks in industrialized countries. Allium hookeri is a wild herb distributed in India and Myanmar. The root of the plant has been used as food and medicine in Southeast Asia. We investigated Allium hookeri extract improves type 2 diabetes mellitus in C57BL/KSJ db/db obese mouse. C57BL/KSJ db/db obese mouse arise out of Type 2 diabetes and we treated Allium hookeri methanol extract 400 mg/kg (AH 400), 800 mg/kg (AH 800), positive control group (thiazolidinedine;TZDs) were administered orally for 8weeks. AH treated group normalized lipid enzyme system (triglyceride, total cholesterol, HDL-cholesterol and LDL-cholesterol) and serum glucose, HbA1c and plasma insulin level. AH treated group recovered ¥â-cell damage by hyperglycemia and fatty liver disease. AH treated group significantly up regulated expression of Peroxisome proliferator- activated receptor gamma (PPAR-¥ã), pyruvate dehydrogenase kinase4 (PDK4), Sterol regulatory element-binding protein 1c (SREBP 1) and fork head box O1 (FOX 01) proteins in C57BL/KSJ db/db obese mouse liver. And we found that AH treated group decreased hepatic malondialdehyde formation in C57BL/KSJ db/db obese mouse liver. These results indicate that Allium hookeri methanol extract might be a potential anti-diabetic agent and could be useful in the treatment of type 2 diabetes mellitus.
|
|
KEYWORD
|
|
Allium hookeri, insulin, proliferator-activated receptor ¥ã(PPAR¥ã), type 2 diabetes mellitus, TZDs (thiazolidinedine)
|
|
FullTexts / Linksout information
|
|
|
|
Listed journal information
|
|
|